EFFECT OF NATURAL ANTIOXIDANTS ON SALIVARY BIOMARKERS OF OXIDATIVE STRESS AND INFLAMMATION IN CHILDREN AT HIGH RISK OF CARIES


Authors: Rafie Ali, Irina Uzunova, Anelia Bivolarska, Ani Belcheva
Keywords: natural antioxidants, salivary biomarkers, childhood caries, reactive oxygen species, caries prevention

Abstract:
Oxidative stress is considered as an imbalance between the production of reactive oxygen species and their elimination by defense mechanisms, which can lead to chronic inflammation. The inflammation caused by oxidative stress is the cause of many chronic diseases. The use of natural products provides an alternative in the construction of new natural antioxidants.
The direct contact of saliva with oral lesions, as well as its simple availability, determine its potential use as a diagnostic medium for early detection of oral diseases. Isolation of appropriate salivary biomarkers allows for timely identification of patients at high risk of caries. Such biomarkers can also be used to assess the status of orally healthy individuals, including when monitoring patients over time.
The proposed review of the specialized dental literature aims to summarize the influence of natural antioxidants on salivary biomarkers of oxidative stress and inflammation in children at high risk of caries.
There are few research on the influence of natural antioxidants on salivary biomarkers is due to the nature of current diagnostics of carious lesion, which is mainly based on visual examinations, optical devices, tactile assessments and radiographs. A review of the literature on different salivary biomarkers can be used to increase the sensitivity of carious lesion detection, as well as to improve strategies for their prevention.Download article