Authors: Stoyan Stoyanov, Silviya Mangarova, Ivan Todorov, Emiliya Kisiova, Maria Magdalena Ignatova, Koni Ivanova
Keywords: pregnancy, serous ovarian tumor, chemotherapy

The incidence of ovarian tumors during pregnancy is from 1: 300 to 1: 556 pregnant. Of all the ovarian tumors during pregnancy, malignant tumors have a frequency of: 1:15000 to 1: 32000.
Case report: I. K. was admitted to Clinic of Gynecology and Obstetrics of the University Hospital Stara Zagora with a diagnosis of Graviditas m.l. IV. Kysta ovarii dextra. Ultrasound revealed a cyst on the right ovary with an oval shape, smooth inner and outer walls, filled with fluid measuring 111/94 mm. diagnosed as early as 8 weeks of gestation. At 14 gest.week. was hospitalized - right adnexectomy and wedge resection of the left ovary with histological result - serous tumor with low malignant potential.
The second patient N.S. at the age of 25 was admitted with an admission diagnosis of Graviditas ml IV. Kysta ovarii sinistra. Ca 125 values at admission were 432 U / ml. Sonography revealed a single ultrasound homogeneous cyst of the left ovary with a diameter of 75/47 mm at 14 weeks of gestation. From histological examination of the tumor formation - left ovary with a serous tumor with a low degree of malignancy.
The first patient underwent 3 cycles of chemotherapy at - 25, 28 and 31 gestational weeks. At 33 weeks, a spontaneous normal vaginal birth followed. In the second patient, a normal fetus was born after a cesarean section.
The combination of ovarian cancer and existing pregnancy is a rarity that raises many questions in diagnostic and therapeutic terms. Finding the right solution is ambiguous due to the unclear impact of pregnancy on ovarian cancer and borderline variants of ovarian tumors.Download article